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8 Viruses 2-7-11 - Viral Life Cycles Viral All viruses must...

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Viral Life Cycles Viral Life Cycles All viruses must: 1. Attach to host cell 2. Transfer viral genome into the host cell 3. Replicate genome 4. Synthesize viral proteins 5. Assemble virus particles 6. Release progeny viruses from host cell
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T4 and M13 Bacteriophages: T4 and M13 Bacteriophages: Infection of Infection of E. coli E. coli Ch 11 Sections 11.1 and 11.2
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T4 Bacteriophage T4 Bacteriophage Structure Icosahedral head containing DNA Tail (neck, internal tube, sheath, base plate, tail fibers) Figure 11.2
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T4 Bacteriophage T4 Bacteriophage Genome Linear dsDNA in phage head (but initially circularizes in E. coli ) 166 kbp 170 genes Figure 11.3, circular map of T4
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Viral Life Cycles Viral Life Cycles All viruses must: 1. Attach to host cell 2. Transfer viral genome into the host cell 3. Replicate genome 4. Synthesize viral proteins 5. Assemble virus particles 6. Release progeny viruses from host cell
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Lambda phage attaches to the maltose porin of E. coli Attach to Host Cell Attach to Host Cell Attachment (or Adsorption) to a host cell receptor Bacterial host cell receptor is normally used for a bacterial function Examples: sugar uptake, iron uptake, conjugation Virus takes advantage of host proteins to infect host cell Figure 6.17
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T4 Bacteriophage T4 Bacteriophage Attachment to E. coli Tail binds LPS/OmpC porin in outer membrane Figure 11.5
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Viral Life Cycles Viral Life Cycles All viruses must: 1. Attach to host cell 2. Transfer viral genome into the host cell 3. Replicate genome 4. Synthesize viral proteins 5. Assemble virus particles 6. Release progeny viruses from host cell
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