9 Viruses 2-9-11-1 - Viral Life Cycles Viral Prokaryotic...

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Viral Life Cycles Viral Life Cycles Prokaryotic cell (e.g., bacteria) Eukaryotic cell (e.g., animal cell) ─ No nucleus, cell wall ─ Replication, transcription and translation in the cytoplasm ─ Nucleus, cell membrane ─ Replication and transcription in the nucleus; translation in the cytoplasm
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Viral Life Cycles Viral Life Cycles All viruses must: 1. Attach to host cell 2. Transfer viral genome into the host cell 3. Replicate genome 4. Synthesize viral proteins 5. Assemble virus particles 6. Release progeny viruses from host cell
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Eukaryotic Virus Life Cycles Eukaryotic Virus Life Cycles Attach to host cell Usually attachment to a specific host receptor Determines host range and tissue tropism Rhinovirus binds an ICAM-1 receptor Figure 6.20
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Eukaryotic Virus Life Cycles Eukaryotic Virus Life Cycles Exception to attachment to host cell receptor Plant viruses Plants have thick cell walls that cover the membrane Usually plant viruses use mechanical transmission Damaged tissue Via animal vector (insects and nematodes) Transmission through seeds
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Eukaryotic Virus Life Cycles Eukaryotic Virus Life Cycles Transfer of viral genome into the host cell Uncoating Injects genome directly (like bacteriophage) Figure 11.16 Direct injection
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9 Viruses 2-9-11-1 - Viral Life Cycles Viral Prokaryotic...

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