12 Genetics 2-18-11 - Regulating Gene Expression Regulating...

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Regulating Gene Expression Regulating Gene Expression Microbes respond to changing environments Alter growth rate Alter proteins produced Must sense their environment Receptors on cell surface Must transmit information to DNA Alter gene expression Change transcription rate Change translation rate
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lacZ lacY lacA β -Galactosidase Lactose permease Transacetylase +1 mRNA Review: Expression of the  Review: Expression of the  lac lac  genes   genes  ( ( lac lac  operon) in   operon) in  E. coli E. coli AUG AUG AUG Stop Stop Stop rbs rbs rbs P DNA Transcription Translatio n protein
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Sensing the Environment Sensing the Environment Two-component signal transduction system Sensor kinase protein in cytoplasmic membrane Binds to signal Activates itself via phosphorylation Response regulator in cytoplasm Takes phosphate from sensor kinase and becomes activated Binds DNA to regulate gene expression Inhibits or stimulates transcription Figure 10.2
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Example - Crown Gall Tumors Example - Crown Gall Tumors Crown galls on alfalfa
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Agrobacterium tumefaciens Agrobacterium tumefaciens
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12 Genetics 2-18-11 - Regulating Gene Expression Regulating...

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