a1 Innate Host Defenses 3-11-11 NEW SECTION

a1 Innate Host Defenses 3-11-11 NEW SECTION - INFECTIOUS...

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PATHOGEN HOST INFECTIOUS DISEASES INFECTIOUS DISEASES Virulence Factors Host Defenses
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Host Defenses Host Defenses 1 st line of defense Block entry of pathogen into body 2 nd line of defense If enters body, internal defenses Phagocytes Complement 3 rd line of defense Immune system Antibodies T cells
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Host Defenses Host Defenses Innate Host Defenses (or Innate Immunity) Against all pathogens, always present, immediate, no memory 1 st and 2 nd lines of defense Physical, chemical and biological barriers Adaptive Host Defenses (or Adaptive Immunity) Against specific pathogens, induced, takes time to develop, memory 3 rd line of defense Immune System
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# Bacterial Cells > # Human Cells Nonpathogenic Mostly beneficial - symbiotic 1. Synthesize vitamins 2. Aid digestion of polysaccharides 3. Protect from pathogens occupy attachment sites produce unfavorable conditions But can be Opportunistic Pathogens (unlike Pathogenic Bacteria - highly virulent) Humans are colonized by huge numbers of Humans are colonized by huge numbers of Microbes Microbes - - Normal Microbiota (Microbiome or Normal Microbiota (Microbiome or Microflora) Microflora)
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Where is the Normal Microbiota? Where is the Normal Microbiota? Skin? Urinary tract? Vagina? Upper respiratory tract? Gastrointestinal tract? Internal tissues? Lungs? Blood? Nervous system? Oral cavity? Eyes? Genital tract?
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Defenses of the Skin Defenses of the Skin Physical Barrier Outer dead layer Sloughing cells Dry Acidic High salt concentration Lysozyme Normal Microbiota (sparse to dense) Adaptive Immunity – antibodies
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Lysozyme Lysozyme Lysozyme Cleaves Figure 3.18 Gram Positive - susceptible Gram Negative - resistant
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Normal Microbiota Normal Microbiota
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This note was uploaded on 01/29/2012 for the course MCB 300 taught by Professor Salyers during the Spring '08 term at University of Illinois, Urbana Champaign.

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a1 Innate Host Defenses 3-11-11 NEW SECTION - INFECTIOUS...

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