DNA Translation - DNA Translation The Mechanism of...

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DNA Translation The Mechanism of Translation Translation involves three steps: 1. Initiation 2. Elongation 3. Termination Initiation Translation begins with the binding of the small ribosomal subunit to a specific sequence on the mRNA chain. The small subunit binds via complementary base pairing between one of its internal subunits and the ribosome binding site, a sequence of about ten nucleotides on the mRNA located anywhere from 5 and 11 nucleotides from the initiating codon, AUG. Figure %: Initiation Once the small subunit has bound, a special tRNA molecule, called N-formyl methionine, or fMet, recognizes and binds to the initiator codon. Next, the large subunit binds, forming what is known as the initiation complex. With the formation of the initiation complex, the fMet-tRNA occupies the P site of the ribosome and the A site is left empty. This entire initiation process is facilitated by extra proteins, called initiation factors that help with the binding of ribosomal subunits and tRNA to the mRNA chain. Termination
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This note was uploaded on 01/27/2012 for the course BIOLOGY BSC1005 taught by Professor Rodriguez during the Winter '09 term at Broward College.

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DNA Translation - DNA Translation The Mechanism of...

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