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Introduction to Mitosi2 - mitotic cyclin degradation{see...

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Introduction to Mitosis Prometaphase Figure %: Prometaphase The major event marking a cell's entry to prometaphase is the breakdown of the nuclear envelope into small vesicles. Kinetochores also become fully matured on the centromeres of the chromosomes. The disruption of the nuclear envelope allows for the mitotic spindles to gain access to the mature kinetochores. As the microtubles of the mitotic spindle enter the nuclear region, some attach to the kinetochores making them kinetochore microtubules. The remaining microtubules are called non-kinetochore microtubules. Sister chromatids are captured by microtubules stemming from centrosomes on opposite ends of the cell. Once they have captured chromosomes, the kinetochore mictrotubles begin to exert force on the chromosomes, moving them. Anaphase
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Figure %: Anaphase Entrance into anaphase is triggered by the inactivation of M phase-promoting factor that follows
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Unformatted text preview: mitotic cyclin degradation {see Mitotic cyclin . During anaphase, the kinetochore microtubules retract, increasing the seperation of the sister chromatids as they are moved further toward the opposite spindle poles. /PARAGRAPH PARAGRAPH Anaphase can be broken into two distinct phases. In the first phase, called anaphase A, chromosomes move poleward, away from the metaphase plate with the retraction of the microtubules. This movement occurs at approximately 2 micrometers per minute (the entire length of a cell is between 10 and 30 micrometers). In the second phase, anaphase B, the mitotic poles marked by the centrosomes themselves separate by the elongation of a specific type of non-kinetochore microtubule, called a polar microtubule. The extent of the separation of the poles varies from species to species. The entire duration of anaphase is relatively short, usually only lasting a few minutes. /PARAGRAPH...
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Introduction to Mitosi2 - mitotic cyclin degradation{see...

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