Structure of Nucleic Acid4

Structure of Nucleic Acid4 - rely on strict patterns of...

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Structure of Nucleic Acids The Importance of the Hydrogen Bond Hydrogen bonding is essential to the three-dimensional structure of DNA. These bonds do not, however, contribute largely to the stability of the double helix. Hydrogen bonds are very weak interactions and the orientation of the bases must be just right for the interactions to take place. While the large number of hydrogen bonds present in a double helix of DNA leads to a cumulative effect of stability, it is the interactions gained through the stacking of the base pairs that leads to most of the helical stability. Hydrogen bonding is most important for the specificity of the helix. Since the hydrogen bonds
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Unformatted text preview: rely on strict patterns of hydrogen bond donors and acceptors, and because these structures must be in just the right spots, hydrogen bonding allows for only complementary strands to come together: A- T, and C-G. This complementary nature allows DNA to carry the information that it does. Chargaff's Rule Chargaff's rule states that the molar ratio of A to T and of G to C is almost always approximately equal in a DNA molecule. Chargaff's Rule is true as a result of the strict hydrogen bond forming rules in base pairing. For every G in a double-strand of DNA, there must be an accompanying complementary C, similarly, for each A, there is a complementary paired T....
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This note was uploaded on 01/27/2012 for the course BIOLOGY BSC1005 taught by Professor Rodriguez during the Winter '09 term at Broward College.

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