{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Kidney Disease Part II

Kidney Disease Part II - Diabetic Nephropathy(DN Learning...

Info icon This preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Diabetic Nephropathy (DN) Learning Objectives Describe the natural progression of DN Describe the effects of blood pressure lowering medications on urinary excretion of albumin Appreciate the anti proteinuric (renoprotective) effect of BP lowering drugs that is independent of their role in BP lowering. Know the clinical and dietary recommendations for slowing the progression of DN (and CKD)
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Diabetic Nephropathy (DN) The leading cause of end stage renal disease Affects 20 30% of individuals with diabetes mellitus Also known as diabetic kidney disease or DKD
Image of page 2
Onset 0 2 – 3 5 10 15 20 25 Stage 1: (onset time of diabetes diagnosis) High GFR and increased kidney size due to glomerular and tubular hypertrophy HTN likely present Stage 2: (onset 2 15 y) Clinically silent Basement membrane thickening and mesangial expansion Stage 3: Incipient Nephropathy (onset 10 15 years) Elevated BP Normalization of GFR Microalbuminuria (30 300 mg/24h) Stage 4: Overt Nephropathy (onset of 15 20 y) Decreased GFR Macroalbuminuria (>300 mg/24h) Stage 5: End Stage (onset 20 25 y) Kidney function loss is up to 3% per month
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern