Lecture 23-24 Notes - Lecture 23 Chronic Kidney Disease...

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Lecture 23 – Chronic Kidney Disease 10/28/2011 Know the risk factors for CKD Identify the central functions of the kidney and describe the consequences of kidney failure Describe the role of the kidney/nephron in filtering blood Recognize the mechanisms by which hyperglycemia can contribute to kidney dysfunction Identify indicators of kidney damage Describe the stages of kidney disease I. INTRODUCTION Kidney diseases affect 20 millions (~11% of US population) Prevalence – 2X in the past 10 years Race - African American Causes (1) DM (40%) i. 40 % T1DM CKD ii. 10% T2DM CKD (2) HTN (28% - damage to renal blood vessels) Mortality – CVD (20x more risk) Stage 5 (treated dialysis) – 22% mortality rate II. CKD – RISK FACTORS
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III. KIDNEY FUNCTIONS Filtration of waste products Maintain homeostasis in blood/tissues Regulation of BP – renin Produce active form of vitamin D – SI (Ca2+ absorption) & Bone (Ca2+ deposition) Production of EPO (RBC production – bone marrow)
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Lecture 23-24 Notes - Lecture 23 Chronic Kidney Disease...

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