Lecture 27 Notes - Lecture 27 - Nutrition and GI disorders...

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Lecture 27 - Nutrition and GI disorders – Part I 11/3/11 Know the basics of GI anatomy and physiology Appreciate the benefits of commensal GI bacteria Describe the following and their treatments ‐GastroesophagealReflux Disease (GERD) and HiatalHernias ‐DiverticularDisease ‐Inflammatory Bowel Disease (IBD) i. Crohn’sDisease (CD) ii. Ulcerative Colitis (UC) Compare and contrast CD and UC I. INTRODUCTION Mouth/Esophagus Stomach Small Intestine Colon - Amylase - CHO digestion - HCl - Pepsinogen - Protein digestion - duodenum,jejunu m,ileum - Majority of absorption - ascending, transverse, descending - Sigmoid Accessory Organs – increase absorption Pancreas (1)Pancreatic Juice
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(2) Bicarbonate (3) Enzymes - Lipase, amylase Gall bladder Bile storage Liver Bile synthesis II. NUTRIENT ABSORPTION Majority of absorption – Ileum (Vitamin B12*) , duodenum and jejunum Fat - Soluble Water-soluble i. Vitamin A,D,E,K ii. Lymphatic system ( lacteal ) Blood iii. Lipoprotein lipase (LPL) Hepatic portal vein Liver (left) Blood Small intestines ( ~11 ft) Folds (of Kerckring) - on mucosa Villi – contains blood capillaries and lymphatic vessels
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Microvilli (brush border) – extension of plasma membrane Colon (~5 ft) Haustra – formed from longitudinal/horizontal muscle contraction Longitudinal muscles (Teni coli) Horizontal Muslces III. Intestinal Bacteria (Luminal flora) Flora = Bacteria (mostly) – 80% 60% of stool Mostly positive effects
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Lecture 27 Notes - Lecture 27 - Nutrition and GI disorders...

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