Lecture 28 Notes - 3. Early appendectomy- Crohm`s UC 4....

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Lecture 28 – GI Diseases Part II 11/8/2011 Broadly identify genetic , environment and causative factors that contribute to the development of Inflammatory Bowel Disease Describe the role of T helper cells in immunity and IBD Appreciate the differences in T helper cell phenotype between CD and UC Identify treatments for IBD and recognize their putative mechanisms Appreciate the utility of probioticsin the treatment of IBD Discuss medical nutrition therapy (MNT) for the IBD patient I. Environmental triggers 1. Non steroidal anti-inflammatory drugs i. Alter GI mucosal barrier enter Enterocytes Inflammation ii. Inhibit COX enzymes ** ASPIRIN Ibuprofen 2. Smoking - Crohm`s ↓UC
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Unformatted text preview: 3. Early appendectomy- Crohm`s UC 4. Lack of breastfeeding- Crohm`s UC 5. Diet (-)Fat/Refined sugar (+) Fruits , vegetables , fiber Effect of NSAIDs COX Pathways II. Causative Agents Types of agents i. Microbial agents -Bacteria (commensal) - antigens + adjuvants (secreted by intestinal bacteria and stimulate immunity )-virus ii. Dietary antigens iii. Luminal antigens Ineffective immune response ( innate ) Over active immune response ( acquired ) Immune response to :-Antigen-Own epithelium III. Helper T-Cells A. Role of Helper T-cells B. Activation of Helper T-Cells C. IBD T Lymphocytes IV. Genetic Susceptibility...
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This note was uploaded on 01/28/2012 for the course NS 441 taught by Professor Caudill during the Fall '11 term at Cornell University (Engineering School).

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Lecture 28 Notes - 3. Early appendectomy- Crohm`s UC 4....

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