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Unformatted text preview: Lecture 30 – Cancer II 11/11/11 Describe the development of cancer Discuss the three types of genes implicated in the development of cancer Appreciate the role of epigenetic alterations in the development of cancer Recognize the 6 hallmarks of cancer Describe the role of angiogenesis (VEGF) and evasion of apoptosis in cancer cell survival (p53) Identify and discuss molecular targets of celebrexin the treatment of cancer I. Development of cancer 1. DNA damages DNA mutation DNA methylation II. DNA MUTATION Oncogenes (controlling cell growth)- Normal= pro-oncogenes Responds to external stimuli (insulin,IGF) - Mutated = oncogenes – mutated genes that lead to abnormal growth Ras activated without external stimuli (Always ON) Tumor suppressor genes (restrain cell growth) Normal genes- no mutation (inhibit cell proliferation) Mutated genes – inactivation of TSG If TWO copies of TSG mutated higher cancer risk p53 – product of TSG that triggers apoptosis DNA repair genes (repair DNA damage) Normal – repair bp mismatch (repair DNA mistakes)...
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This note was uploaded on 01/28/2012 for the course NS 441 taught by Professor Caudill during the Fall '11 term at Cornell.
- Fall '11