Lecture 34 Notes - ii. Higher intake high use of choline as...

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Lecture 34 – Choline II ( Part II) 12/1/11 1. MATERNAL INTAKE – CHOLINE METABOLISM (P* group) - Higher choline intake higher free choline, betaine & DMG - Higher choline increases as main methyl donor higher SAM Higher DNA methylation - Higher maternal intake No urine excretion alteration Both groups had same urinary excretion (CHOLINE) (FOLATE) 1/3 excretion – high given RDA - Higher maternal intake increases fetal use of methyl donor (in baby) i. DMG NOT from placenta
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Unformatted text preview: ii. Higher intake high use of choline as methyl donor by BABY 3. MATERNAL INTAKE METABOLITES-intake methylation gene expression metabolism-Metabolite profiling i. Higher intake Low normal cortisol ii. 4. MATERNAL INTAKE CORTISOL (HPA Axis)-Cortisol = END PRODUCT of HPA Axis (1) Higher Choline intake Higher methylation lower CRH expression (Placenta) (2) Lower HPA Axis Lower cortisol in BABY...
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Lecture 34 Notes - ii. Higher intake high use of choline as...

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