Lecture 5 Notes - Lecture 5 Vitamin D Readings Vitamin D: A...

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Lecture 5 – Vitamin D 09/15/2011 Readings Vitamin D: A D-Lightful Solution for Health (Michael Holick) I. BACKGROUND II. SOURCES NATURAL FORTIFIED - Wild salmon - oily fish - Cod liver oil - Mushrooms - Milk - Dairy product (yogurt) - Cheese - Cereals - Juice III. FORMS/TYPES VITAMIN D 3 (Cholecalciferol) VITAMIN D2 (Ergocalceferol) - Produced in skin - Produced from lanolin (for fortification and supplement) - From yeast and mushroom (exposed to UV) - Pharmaceutical use IV. SYNTHESIS
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V. VITAMIN D STATUS Serum calcidiol concentration (25(OH)D) - Optimal = 35-55 ng/mL (or 40-60) - Deficiency = 10- 15 ng/Ml (+) - Reflects Vitamin D from sun, diet, supplementation - Long half time ( 15 days) (--) - Vitamin D in tissues not included Circulating (25(OH) 2 D) (--) - Short half time (15 hours) - High regulation from parathyroid hormones, Ca , Phosphate Cutoffs VI. FUNCTIONS A. Bone Health 1. Fracture Risk 2. Fall Prevention - Vitamin D ( >400 IU/day) reduces fractures ( in older) - 25(OH)D (>75 nmol/L) - optimal prevention
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This note was uploaded on 01/28/2012 for the course DSOC 306 taught by Professor Stoltzfus during the Spring '11 term at Cornell University (Engineering School).

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Lecture 5 Notes - Lecture 5 Vitamin D Readings Vitamin D: A...

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