Lecture 15 Notes - TB - SSA highest prevalence MDG goal box...

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Lecture 15 – Tuberculosis 11/1/11 Chapter 4 – Clinical Features/ Pathophysiology Clinical Features Pathophysiology Role of Nutrition Evidence N.B: Most vulnerable (1) children (2) Immuno-compromised (3) elderly Lecture 15 – Tuberculosis 11/1/11 I. TB – Introduction TB caused by Mycobacterium tuberculosis (affects 1/3 of global population) Top 10 mortality causes ( even if curable infection) II. Transmission (droplet) III. Definition - Pulmonary TB vs extra-pulmonary TB - Latent TB vs Active TB - Multi-drug resistant TB vs Extensively DR TB IV. Natural History - 2-8 wks – CMI develops - > 2 years (10%) risk to go from infection diseases - HIV – affects CMI (Higher risk) - HIV – faster progression
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V. Clinical presentation - persistent cough - fever - night sweats - Hemoptysis (bloody cough) - Weight loss (malnutrition) - shortness of breath VI. Diagnosis - Sputum microscopy - TB culture N.B : Harder to diagnose in children HIV – TB LINK VII. Treatment - Short-course chemotherapy - DOTS – Directly Observed Treatment (Short-Course)
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VIII. Epidemiology
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Unformatted text preview: SSA highest prevalence MDG goal box Stop TB partnership (Key messages) i. Mortality has been falling since 2006 ii. Incidence has been falling since 2002 iii. 50 % REDUCTION (1990-2015) IX. Malnutrition and TB TB - WASTING-Decreased appetite-Increase losses (macro-/mico-nutrients)-Altered metabolism/absorption of nutrients BMI TB- BMI = 14% risk (for TB) X. TB- Micronutrient-Vitamin D supplement = Radiological improvement-Vit A + Zinc- sputum conversion ( +ve -ve)-Micronutient supplement reduce (1) reoccurrence (2) peripheral neuropathy NO effect (1) Weight gain (2) Anemia (3) mortality-Micronutrient + Zinc lower mortality in HIV infected weight gain TB- Wasting strong association Nutrition no single nutrient recommended Poor nutrition - (1) high risk TB (2) more active (3) morbidity associated Target = malnourished population Intervention= Nutritional support...
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This note was uploaded on 01/28/2012 for the course DSOC 306 taught by Professor Stoltzfus during the Spring '11 term at Cornell University (Engineering School).

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Lecture 15 Notes - TB - SSA highest prevalence MDG goal box...

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