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NS4410_Cancer_2011_Part II(1)

NS4410_Cancer_2011_Part II(1) - Cancer II Learning...

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Cancer II Learning Objectives Describe the development of cancer Discuss the three types of genes implicated in the development of cancer Appreciate the role of epigenetic alterations in the development of cancer Recognize the 6 hallmarks of cancer Describe the role of angiogenesis (VEGF) and evasion of apoptosis in cancer cell survival (p53) Identify and discuss molecular targets of celebrex in the treatment of cancer
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Cancer cell division Fourth or later mutation Third mutation Second mutation First mutation Uncontrolled growth Cell Suicide or Apoptosis Cell damage— no repair Normal cell division Old or damaged cells self destruct. Rates of cell growth and cell death are kept in balance Cancers arise from mutations in DNA and a loss of control over normal cell growth
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Chromosomes are DNA molecules Heredity Radiation Chemicals Viruses Chemicals and radiation damage genes Viruses introduce their own genetic material into cells Heredity passes on alterations in genes that make a person more susceptible to cancer Cancer Initiation: DNA/Gene Mutations
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Oncogenes Mutated forms of normal genes involved in controlling cell growth Tumor Suppressor Genes Normal genes that restrain cell growth and division. Absence of these genes results in cancer DNA repair genes Mutated forms (non functional) of genes that repair DNA damage Three types of genes implicated in the development of cancer
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