Lect36-38powerpoint

Lect36-38powerpoint - E n d o c r in o lo g y ( 6 le c t u...

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1 Endocrinology (6 lectures) Lecture 36: Principles of Endocrinology Lecture 37-38: Central Endocrine Glands Lecture 39: Peripheral Endocrine Glands - Thyroid and Adrenal Lecture 40: Peripheral Endocrine Glands - Fuel Metabolism Lecture 41: Peripheral Endocrine Glands - Calcium Metabolism Lecture 36: Principles of Endocrinology Reading: principles of hormonal communication, comparison of endocrine and nervous systems, general principles of endocrinology
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2 Endocrinology - study of the control of physiological processes by the system of cells, tissues, organs and glands that secrete hormones. Hormone - chemical produced by one cell which enters the bloodstream, is transported to a different body location, and then binds to a specific receptor on a target cell(s), altering function of the target: change, divide (mitogenic), or die (apoptotic). Endocrine System
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3 Nervous System - rapid, short-acting signals - precise, direct interconnections Endocrine System - slower acting, longer lasting signal - diffuse, indirect connections (via blood) - Neurons can secrete hormones (neurohormones) - Nervous system can influence secretion of hormones - Hormones can influence function of nervous system Human Body Has Two Major Control Systems Endocrine Signaling Fig 18-4, 5th edition only
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4 General Functions of Endocrine System 1) Homeostasis - regulates composition and volume of ECF - controls energy production - controls digestive tract and organ function - induces adaptation to hostile environment 2) Reproduction 3) Growth and development 4) Behavior Some illustrations of the importance of the endocrine system patient with a goiter gigantism or dwarfism circadian rhythms
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5 Endocrine Signaling Fig 18-4, 5th edition only Tropic vs non-tropic hormones Tropic hormones stimulate and maintain their endocrine target tissues e.g. TSH Non-tropic hormones exert effects on non-endocrine target tissues e.g. Thyroid hormone
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6 Criteria for determining if a chemical is a hormone: - gland removal leads to specific homeostatic problem (i.e. remove adrenal cortex, excessive Na loss, death) - extracts from gland correct problem - purified hormones (synthetic) correct problem - time-course of hormone release is physiologically relevant Endocrine Signaling synthesis, storage, secretion, transport 3 Classes of Hormones 1) peptides and proteins 2) amines 3) steroids Fig 18-4, 5th edition only
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7 (1) Peptide and protein hormones small chains of amino acids (3-200 aa long)
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This note was uploaded on 01/29/2012 for the course NPB 101 taught by Professor Fuller,charles/goldberg,jack during the Winter '08 term at UC Davis.

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Lect36-38powerpoint - E n d o c r in o lo g y ( 6 le c t u...

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