lecture17_Muscle3

Lecture17_Muscle3 - Muscle Physiology 3 Reading ch 8 pgs 276-281,289-299 Muscle Metabolism ATP provides the sole energy source for muscular

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Muscle Physiology 3 Reading : ch 8, pgs 276-281,289-299
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Muscle Metabolism - ATP provides the sole energy source for muscular activity: the power stroke and the active transport of Ca ++ . The ATP is derived from 3 metabolic sources: 1) Creatine Phosphate - provides a reserve of high energy phosphate for synthesis of ATP (1 st source tapped). - during rest, excess ATP generated by glycolysis and oxidative phosphorylation, is converted to creatine phosphate that is stored by muscle cells as an energy reserve. creatine kinase creatine phosphate + ADP creatine + ATP 2) Oxidative Phosphorylation - aerobic metabolism of glucose and fatty acids. Makes use of the high myoglobin content of muscle. 3) Glycolysis - anaerobic metabolism of glucose. The biproduct, excess pyruvic acid, is converted to lactic acid that is removed by the bloodstream. (performance enhancement)
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ATP is derived from 3 metabolic sources : 1) Creatine Phosphate 2) Oxidative Phosphorylation 3) Glycolysis
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* Fatigue - inability of muscle to maintain tension. Can result from muscle fatigue or neuromuscular fatigue . Recovery - replenishment of muscle glycogen and creatine phosphate following intense activity. Muscle fatigue - occurs when an exercising muscle can no longer respond to stimulation with the same degree of contractile activity. 2 primary factors 1) Depletion of energy reserves 2) Accumulation of lactic acid from glycolysis, which may inhibit enzymes involved in the contraction coupling process. Neuromuscular fatigue
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This note was uploaded on 01/29/2012 for the course NPB 101 taught by Professor Fuller,charles/goldberg,jack during the Winter '08 term at UC Davis.

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Lecture17_Muscle3 - Muscle Physiology 3 Reading ch 8 pgs 276-281,289-299 Muscle Metabolism ATP provides the sole energy source for muscular

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