lecture30_Resp3

lecture30_Resp3 - Respiratory Physiology III hemoglobin-...

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Unformatted text preview: Respiratory Physiology III hemoglobin- soluble cytoplasmic protein in erythrocytes that reversibly binds 4 molecules of O 2 . Hb + O 2 HbO 2 reduced hemoglobin oxyhemoglobin- Hemoglobin has 4 heme groups (each with an iron atom), each of which can reversibly combine with an O 2 molecule.- As a result, hemoglobin can reversibly bind 4 molecules of O 2 . hemoglobin saturation- proportional to the P O2 of the blood and follows a non-linear S-shaped function known as the oxygen-hemoglobin dissociation curve Factors Influencing the Dissociation Curve : CO 2- CO 2 shifts the dissociation curve to the right, decreasing the affinity of Hb for O 2 . pH- H + shifts the dissociation curve to the right, decreasing the affinity of Hb for O 2 . temperature- an increase also shifts the dissociation curve to the right, decreasing the affinity of Hb for O 2 . The reduced P CO2 , higher pH, and lower temperatures in the pulmonary capillaries have the opposite effect and shift the dissociation curve to the left, thereby increasing the affinity of Hb for O...
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lecture30_Resp3 - Respiratory Physiology III hemoglobin-...

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