Iron+and+Health+for+bSpace

Iron+and+Health+for+bSpace - Iron and Health (4/11/11)...

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Iron and Health (4/11/11) Recommended Readings: nd  ed, Chapter 12,  section on Iron.
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Important Words Anemia Blood Cell Erythrocytes Ferritin Hematocrit Heme Heme iron 2 Hemochromatosis Hemoglobin Myoglobin Non-heme iron Iron Iron deficiency Pernicious anemia Sickle cell anemia
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Lecture Outline Components of blood and their roles Functions of iron Iron homeostatis (ie. How we regulate iron  amount in our bodies) Iron deficiency Iron overload Summary 3
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Essential Roles of Blood (In with the good. Out with the bad.) Transport to and from tissues  Nutrients Oxygen Chemicals needed for metabolism, immune  function etc Removal of waste products including Carbon dioxide Urea 4
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Four Main Components of Blood Essential for blood clotting Essential for immune function Essential for oxygen transport Solute for important molecules 5
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The % of blood volume occupied by RBC’s One method of assessing iron status Low hematocrit (<40 males; <36 females) % of blood occupied by RBC’s is too low  Could be due to anemia, or blood loss  High hematocrit (>54 males; > 47 females) % of blood occupied by RBC’s to too high Could be due to dehydration, doping Hematocrit 6
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Lecture Outline Components of blood and their roles Functions of iron Iron homeostatis (ie. How we regulate iron  amount in our bodies) Iron deficiency Iron overload Summary 7
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Functions of Iron 1. Oxygen and CO 2  transport 8
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2 and CO 2 to be Bound to Hemoglobin (in blood) and Myoglobin (in muscle) Hemoglobin = 4 heme units + 4 protein (globin) units Myoglobin = 1 heme unit + 1 protein (globin) unit Zinc is needed to chemically insert the Fe into the heme molecule. 9
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Iron+and+Health+for+bSpace - Iron and Health (4/11/11)...

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