Koofer - 10f4 BIS 102 Fall,2011 K. Hilt Nmne _~K~-LastJ...

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10f4 BIS 102 Fall,2011 K. Hilt Nmne ________ ~K~~~------------------- LastJ First Second Midterm Score (tOO): ___ _ Equations: pH = pKa + log {[b ]/[ an AO = MI - TAS pKa's ofmnino acid side chains: D (3.9), E (4.2), H (6.0), C (8.3), Y (10.1), K (10.5), R (12.5) pKa ofmnino acid a-COOH (2.1); pKa of amino acid a-NH3+ (9.6) pKa of oligopeptide N-terminus (7.4); pKa of oligopeptide C-terminus (3.6) pKa ofNH4 + (9.25) 1. (5 pts.) Antibodies have several disulfide bonds. These tetramers are secreted into the blood. The disulfide bonds would be considered to be part of (circle the letter of the best answer): a) 1° and 2° structure b) 2° and 3° structure c) 1 ° and 3° structure CID 1 ° and structure e) 3° and 4° structure '" -s-~ ... / ,,<r: s-s 2. (15 pts.) There are three important histidine residues in Hb. Identify them; rank them, and explain what each one does. If they do more than one thing, then list them all. Limit your answers to the lines provided. # 1 in importance Nmne: f.,. t:::rI, ~ "'" J. \-\ Function(s): \) \ ;~\l. .). . t"'\.D"~""'(i~ ~ Fe+z- -\-0 'MO~ at sokt- 'o'(\J. .~. "l-) @'f"u+ev+s '\:x.:c. .\(. 'i2~tk. . rl=- 'F-e. .-r"2. fy"r?t reo. .d-a'ry \,.7,tt. ... ~7. .0 #2 in importance Nmne: J),'S+~ H #3 in importance
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This note was uploaded on 01/30/2012 for the course BIS 101/102 taught by Professor Etzler during the Spring '10 term at UC Davis.

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Koofer - 10f4 BIS 102 Fall,2011 K. Hilt Nmne _~K~-LastJ...

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