Thrombophilia

Thrombophilia - Thrombophilia Thrombophilia A pediatric...

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Thrombophilia Thrombophilia A pediatric perspective. Craig Dobson, MD CPT, MC, USAR NCC Pediatrics Residency Program
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Definitions Definitions Unexpected tendency to form clots under inappropriate circumstances. Family history of vascular disease under age 50. Incl. MI, CVA or DVT.
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Case Case 9yo male at presents for eval for psych admission to CNMC for acute psychosis. Disorganized behavior, non-communicative except occasional screaming fits. Associated symptoms headache, high fevers, occasional watery stools. Head CT with contrast notes lateral venous sinus thrombosis. But why?
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Epidemiology Epidemiology Venous thrombosis lifetime prevalence 5- 10% of total population. Highest incidence in neonatal and post- pubertal. Neonates 5/100k. Teens incidence 23/100k.
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Neonatal Presentation Typically in-utero or within first 48hrs of life. Catheter thrombosis. Still requires evaluation. Renal vein thrombosis Flank mass on exam Thrombocytopenia, HTN, hematuria. Seizures from CVA or lesion on head U/S. Neonatal Purpura Fulminans
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Thrombophilia - Thrombophilia Thrombophilia A pediatric...

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