LS_2_Lec_3_Membrane

LS_2_Lec_3_Membrane - 1/5/12 1 Life Sciences 2 Membrane...

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Unformatted text preview: 1/5/12 1 Life Sciences 2 Membrane Physiology & Signaling Chapters 6 & 7 Dr. Joseph Esdin Cells 1/5/12 2 Blood Cells & Their Environment Environment of the Interstitial Fluid Concentration of energy-rich molecules Concentration of O 2 and CO 2 Concentration of waste products pH Concentration of water, salt, and other electrolytes Temperature 1/5/12 3 Variation of Cells Neuron Epithelial cell Muscle cell Cholesterol Glycoprotein Glycolipid Various membrane proteins Channel Intracellular fluid Phospholipid Fluid Mosaic Model Extracellular fluid 1/5/12 4 Membrane Composition and Structure All biological membranes contain proteins Many membrane proteins have hydrophilic and hydrophobic regions The association of protein molecules with lipid molecules is not covalent Peripheral proteins Membrane Composition and Structure Integral proteins 1/5/12 5 Membrane Composition and Structure Integral membrane proteins have hydrophobic regions of amino acids that penetrate or entirely cross the phospholipid bilayer Peripheral membrane proteins are found on one side of the membrane Membrane Composition and Structure Some cells have carbohydrates associated with their external surfaces Carbohydrate-bound lipid is called glycolipid Most of the carbohydrate in the membrane is covalently bonded to proteins, forming glycoproteins 1/5/12 6 Membrane Composition and Structure Two types of proteins may be in the membrane Integral proteins Peripheral proteins These proteins function in Junctions Pathway/transport Chemical signals Cell-To-Cell junctions Allow the interaction in between neighboring cells Three different types Desmosomes Tight junctions Gap junctions 1/5/12 7 Desmosomes Desmosomes Tight junctions Push cells very close to each other to minimize space in between them to prevent ______ pathways Tight Junctions 1/5/12 8 Transcellular pathway Paracellular pathway Tight junction Tight Junction Gap Junctions Gap junction 1/5/12 9 Gap Junctions Membrane of cell 1 Membrane of cell 2 Gap junctions Small ions and molecules pass through Large molecules can not pass through Longitudinal section Connexon Connexon Cell and Its Surroundings What factors determine how substances move in and out of the cell? the cell?...
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LS_2_Lec_3_Membrane - 1/5/12 1 Life Sciences 2 Membrane...

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