sicklePresen - Genetic Counseling for Sickle Cell Anemia...

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Genetic Counseling for Sickle Cell Anemia Anthony Fortuna Thomas Ward
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What is Sickle Cell Anemia? Substitution of a single amino acid into a hemoglobin protein of red blood cells resulting in the cell assuming a “sickle” shape and increasing in hardness Sickle Cell has a tendency to clump and clot in blood cells, resulting in several complications, including strokes and infections Early Death Results
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Affected Population 1 of 10 African Americans 20-40% in Sub-Saharan Africa are Heterozygotes Strange for such a lethal gene to have such a high prevalence in a population Why?
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Sickle Cell Anemia, Heterozygotes Gene is Autosomal Co-dominant Homozygotes Have Mutated Allele From Both Parents Severely Reduced Life Expectancy Heterozygotes Gene is codominant, both sickle and normal cells produced Resistance to malaria
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Malaria Plasmodium Parasite Causes malaria Heterozygotes can
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This note was uploaded on 01/31/2012 for the course BIOL 1107L taught by Professor T.a. during the Fall '08 term at University of Georgia Athens.

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sicklePresen - Genetic Counseling for Sickle Cell Anemia...

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