aspirin - The Synthesis of Aspirin Connie Jamieson...

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The Synthesis of Aspirin Connie Jamieson 11/24/2011 Chemistry 212 section 205 Tiffany Ha Lab Partner: Andrew Cedeno Conclusion: Aspirin is one of the most commonly used over the counter drug in the world. The average aspirin tablet contains approximately 325mg. of acetylsalicylic acid with an inert binding material such as starch. Aspirin is used to reduce inflammation, lower fever and to relieve pain. Originally, aspirin was derived by boiling the bark of the white willow tree. The salicin in the willow bark had analgesic properties; purified salicylic acid was bitter and irritating when taken orally. Salicylic acid was neutralized with sodium to produce sodium salicylate, which tasted
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better but still irritated the stomach. Salicylic acid could be modified to produce phenylsalicylate, which was better tasting and less irritating, but released the toxic substance phenol when metabolized. Felix Hoffman first synthesized the active ingredient in aspirin, acetylsalicylic acid, in 1893. The purpose of this experiment was the synthesis of aspirin, acetylsalicylic acid, from salicylic acid and acetic anhydride, refer to figure 1, and to determine the percent yield of the aspirin synthesized experimentally. Figure The aspirin was synthesized through the reaction of salicylic acid by acetylation with acetic anhydride and crystallization. Crystallization is the process of arranging atoms or molecules in a liquid state into an ordered solid state. When the salicylic acid was combined with acetic anhydride aspirin and acetic acid were formed when an acetyl group, H3CCOO, replaced the
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This note was uploaded on 02/02/2012 for the course CHEMISTRY 212 taught by Professor Ha during the Spring '11 term at George Mason.

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aspirin - The Synthesis of Aspirin Connie Jamieson...

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