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Unformatted text preview: Biology 232 Exposure & Epidemiology Fall 2010 1 Exposure Assessment • Goal is to quantify exposure (routes = ingestion, inhalation, dermal contact) • Requires understanding of fate and transport and toxicology (effect in body) Exposure pathway - begins with environmental source o Coal with mercury – combusted, mercury in exhaust particulates • Via fate and transport , contaminant reaches micro- or personal environment o People living down wind of coal plant breath in plume o Particulates settle into water, enter food web • Ends with exposure: contact between a toxicant and the human envelope o Animal protein with accumulated mercury ingested by human Be sure to know other examples (from F& T to contact; e.g.; nitrate, arsenic, etc) Quantifying exposure: units of absorbed dose: mg / (kg*day) • Mass of toxicant (ug/L); normalized to body weight; averaged over time: Trichloroethylene contamination of groundwater: concentration = 5 ug/L Person ingests 2L/day well water; Person weighs 70 Kg (assume 100% absorption) • 5 ug TCE/L x 2 Lwater/day x 1/70 kg • = 0.143 ug TCE/kg*day • Use of Geographic information systems (GIS) in assessing exposure (UST leak in groundwater; map of neighborhood wells)...
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- Fall '10
- Epidemiology, exposure