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Unformatted text preview: HO M E | S UB S CR I B E F O R F R E E ! | A RT I CL E S | B UY E R' S G U ID E | W E B I N A R S | JO B B O A RD | A DV E RT I S I NG W e d n e s d a y , A p ri l 0 7 , 2 0 1 0 EVENTS EDITORIAL CONTACT US View Article Archives Site Search: Go Subscribe to receive more articles like this: Print/digital | Webfeed (RSS) New Tools Enhance Forensic DNA Casework Analysis By: Arthur Eisenberg, PhD and Lisa Schade, BS, MHR Issue: February/March 2010 New laws are increasing DNA caseloads, but recent and upcoming technology is helping to close the gap and improve the quality of forensic DNA testing and analysis. Over the past fifteen years numerous scientific improvements have advanced the field of forensic DNA testing, significantly altering the way evidence is processed and greatly enhancing its role within the criminal justice system. The utilization of PCR based methods has progressed from D1S80 amplified fragment length polymorphism analysis and DQA1 &amp; Polymarker Reverse Dot Blot Hybridization assays to todays highly discriminatory multiplex STR systems. These technological advances now enable increasing amounts of genetic information to be obtained from limited quantities of a wide variety of extremely challenging samples that previously yielded little or no results, leading to a greater reliance on, and demand for, DNA testing in criminal cases. The proven success of leveraging DNA during the investigative process has driven the passage of new legislation, increased sharing of DNA information between countries, and initiated a rigorous evaluation of the use of DNA for a larger number and wider variety of criminal cases. Investigators now routinely rely on the results of forensic DNA analysis and have a greater understanding of its impact on their cold and active cases. As a result, there is a growing expectation among investigators and attorneys that the scientific limitations of DNA testing will continue to dissolve and that more cases will be resolved using DNA testing. In response to the increased demand for DNA analysis, laboratories are continuously implementing improved methods that allow them to process database and casework samples more efficiently. Recent advances, including automatable extraction methodologies, the availability of a predictive dual quantitation assay that allows assessment of the potential probative value and performance of a sample in downstream analyses, the development of next generation STR multiplexes and mini-STR kits1 that improve performance on degraded and compromised samples, and expert system analysis software, 2 all combine to provide DNA analysts with an expanded set of capabilities in their forensic tool-box. These tools better equip them to meet the needs of law enforcement and provide results that enhance their database and casework analysis while speeding up the overall process....
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- Fall '11
- DNA, National DNA database, Casework Analysis, Forensic DNA Casework, DNA Casework Analysis, Enhance Forensic DNA