13 - Channels - Ion Channels Learning Objectives Active and...

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Ion Channels • Ligand-gated Ion Channels • KcsA and mechanisms of ion permeation Learning Objectives • Voltage-gated Ion Channels • Blockers of Ion channels • Active and Passive Transport of Ions
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Active and Passive Transport
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Ion Carriers and Ion Channels Fig. 10-1
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Valinomycin Fig. 10-2
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KcsA, a Bacterial K + channel Fig. 10-4A
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The Permeation Pathway Fig. 10-4B
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The Mechanism of Ion Permeation Fig. 10-5
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Nicotinic Acetylcholine Receptor
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Ligand-Gated Ion Channels • Example: nicotinic acetylcholine receptor. Agonist: acetylcholine. Antagonists: bungarotoxin, tubocurarine, myorelaxants Agonist binding site Receptor contains 5 pseudo- symmetric subunits One subunit has 4 transmembrane helices Top View Side View
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Bungarotoxin IVCHTTATSP ISAVTCPPGE NLCYRKMWCD AFCSSRGKVV ELGCAATCPS KKPYEEVTCC STDKCNPHPK QRPG
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Tubocurarine d-tubocurarine is one of the active components of the arrow poison (curare) of South American Indians.
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