18 - Glycogen - Glycogen Metabolism and Gluconeogenesis...

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Glycogen Metabolism and Gluconeogenesis Learning Objective • Glycogen structure Learning Objectives • Glycogen breakdown • Enzymes catalyzing glycogen breakdown • Glycogen synthesis •S ynthesis of glucose
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Glucose Storage and Synthesi Glucose Storage and Synthesis • Brain, red blood cells and some other tissues depend almost entirely on glucose as the source of energy • Glycogen is the stockpile of glucose for later metabolic use • A constant concentration of glucose in blood (~ 5 mM) is provided by glycogen mobilization
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Glucose Storage and Synthesi Glucose Storage and Synthesis • Mobilization of glucose from glycogen occurs Mobilization of glucose from glycogen occurs primarily in the liver • After the meal, glucose is plentiful. Glycogen is synthesized • Liver glycogen can supply brain and erythrocytes with glucose for ~ 12 hours • Under fasting conditions, glucose is synthesized from noncarbohydrate precursors (e g amino acids) – noncarbohydrate precursors (e.g., amino acids) gluconeogenesis
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Overview of Glucose Metabolism Fig. 16-1 G6P is produced by: - phosphorylation of free glucose - glycogen degradation - gluconeogenesis
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The Structure of Glycogen Fig. 16-2a • Reducing end: the sugar whose anomeric carbon
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This note was uploaded on 02/06/2012 for the course BIOCHEM 2ee3 taught by Professor Zhorovb during the Spring '10 term at McMaster University.

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18 - Glycogen - Glycogen Metabolism and Gluconeogenesis...

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