19 - Citric Acid Cycle, Part 1

19 - Citric Acid Cycle, Part 1 - Citric Acid Cycle Part I...

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Citric Acid Cycle. Part I. Learning Objectives • The hub of intermediary metabolism • General features of the citric acid cycle • The hub of intermediary metabolism • Pyruvate dehydrogenase multienzyme complex
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Overview • In aerobic organisms, metabolic fuels • The citric acid cycle is a central are oxidized in the citric acid cycle. pathway for obtaining energy from carbohydrates, fatty acids, and amino acids Fig. 17-1 • Before entering the citric acid cycle, the metabolic fuels are decomposed acids. the metabolic fuels are decomposed and transformed to two-carbon acetyl groups -CO-CH 3 . •The acetyl groups are attached to CoA to form acetyl-CoA.
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Oxidative Fuel M t b li Metabolism • Intermediates of the citric acid Intermediates of the citric acid cycle contain four to six carbon atoms and one to three b li • Acetyl groups derived from Fig 17-1 carboxylic groups. carbohydrates, amino acids, and fatty acids, enter the citric acids cycle. Fig. 17 1 • In the citric acid cycle, the acetyl groups are oxidized to acetyl groups are oxidized to CO 2
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The Reactions of the Citric Acid Cycle • The net reaction of the citric acid cycle: The net reaction of the citric acid cycle: 3 NAD + + FAD + GDP + P i + acetyl-CoA ! 3 NADH + FADH 2 + GTP + 2CO 2 + CoA 2 • The citric acid cycle is a series of eight reactions in which the acetyl group of acetyl CoA is oxidized to two molecules of CO acetyl group of acetyl-CoA is oxidized to two molecules of CO 2 . • In the oxidation process, four pairs of electrons are released. Three pairs of electrons are consumed in the reduction of three NAD + to three NADH. One pair of electrons is consumed in the reduction of FAD to FADH 2
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The Reactions of the
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