27 - Amino Acid Metabolism, Part 1

27 - Amino Acid Metabolism, Part 1 - Amino Acid Metabolism....

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Amino Acid Metabolism. Part I. ! ! Turnover of proteins ! Transamination and oxidative deamination ! Toxicity of Ammonia L e arning Obj ec t iv s Extracellular and intracellular degradation of proteins
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Proteins Turnover ! There is no storage pool for amino acids analogous to that for glucose (glycogen) or fat acids (triacylglycerols). excess amino acids are converted in metabolic fuels.
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Proteins Turnover ! Proteins are constantly synthesized and degraded by the cell. This process is necessary for: - Storage of amino acids in the form of dynamic pool; - Elimination of abnormal proteins that may randomly arise from normal proteins because of thermal motion; - Elimination of excessive enzymes, regulatory and transport proteins, a part of metabolic control.
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Half-Life Time of Some Proteins Protein Half-life time, h Ornithine decarboxylase 0.2 PEP carboxylase 5.0 Aldolase 118 Cytochrome c 150 ! Enzymes with the short lifetime are at the important points of metabolic control ! Enzymes with the long lifetime have constant catalytic activities
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Lysosomes ! Lysosomes are organelles containing around 50 hydrolytic enzymes involved in intracellular digestion. ! Lysosomes fuse with membrane-enclosed particles that contain: - substances imported to the cell via endocytosis - intracellular substances targeted for degradation ( va c uol e s )
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Lysosomes ! Inside the lysosome, pH 5 cytosolic pH 7 Lysosomal [H
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This note was uploaded on 02/06/2012 for the course BIOCHEM 2ee3 taught by Professor Zhorovb during the Spring '10 term at McMaster University.

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27 - Amino Acid Metabolism, Part 1 - Amino Acid Metabolism....

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