29 - Nucleotide Metabolism

29 - Nucleotide Metabolism - Nucleotide Metabolism !...

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Unformatted text preview: Nucleotide Metabolism ! DNA-specific metabolites ! Synthesis of ribonucleotides ! Synthesis of thymine ! Cancer chemotherapy ! Nucleotide degradation L e arning Obj ec t iv e s Nitrogenous Bases ! Bases are structural derivatives of either purine or pyrimidine ! Nucleotides are composed of a nitrogenous ba s e linked to a sugar to which a phosphate group is attached. purine pyrimidine N N H N N N N Base, Nucleoside, and Nucleotide NH 2 NH 2 O 1 3 4 2 H H OH H OH H 2- O 3 P-O-CH 2 5 N NH 2 O 1 3 4 2 H H OH H OH H CH 3 5 Ba s e Nu c l e o s id e Nu c l e o t id e N N H N N Adenine Adenosine Adenosine monophosphate N N N N N N N Functions of Nucleotides ! Almost all sells can synthesize nucleotides d e novo .- coenzymes: FAD, NAD, CoA ! Nucleotides are components of :- high-energy compounds, e.g. ATP, Adenosine triphosphate GTP, Guanosine triphosphate UTP, Uridine triphosphate CTP, Cytidine triphosphate- nucleic acids ! Nucleotides do not provide significant amount of metabolic energy. Synthesis of Ribonucleotides O O H H OH H OH H 2- O 3 P-O-C H 2 N N N HN ! AMP and GMP are synthesized from inosine monophosphate (IMP). Inosine monophosphate, a precursor of AMP and GMP ! Before being incorporated into nucleic acids, nucleoside monophosphates are converted to nucleoside triphosphates....
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This note was uploaded on 02/06/2012 for the course BIOCHEM 2ee3 taught by Professor Zhorovb during the Spring '10 term at McMaster University.

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29 - Nucleotide Metabolism - Nucleotide Metabolism !...

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