GAS - Endocrine system Includes all cells and endocrine...

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Includes all cells and endocrine tissues that produce hormones or paracrine factors Endocrine system Any chemical substance produced in one area of the body Transported via blood to another area An action is initiated by the presence of the chemical
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Hormones can be • Freely circulating • Rapidly removed from bloodstream
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1. Receptors in the cell membranes of target cells Mechanisms of hormone action 2. Lipid Derivatives - steroid hormones cross the membrane bind to receptors cytoplasm nucleus Amino Acid Derivatives - thyroid hormones, NE, epinephrine
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Mechanism of Hormone Action 1. Cells release hormones in the blood 2. Target cell receptor picks up hormone 3. Binding to receptor initiates changes in Shape, activities and # ` s of enzymes and proteins Target cell sensitivity is due to # of hormone receptors on the cell 4. Messenger system of hormones a. Hormone itself = 1st messenger b. Second messenger is a molecule generated inside the cell though enzyme activity from hormone binding c. This 2nd messenger has specific effect I.e. inhibit or activate cell action
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Figure 18–3
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GAS - Endocrine system Includes all cells and endocrine...

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