Open Yale CoursesCHEM 125: Freshman Organic ChemistryLecture 18 - Amide, Carboxylic Acid and Alkyl Lithium<< previous session| next session >>Overview:This lecture completes the first half of the semester by analyzing three functional groups in terms of theinteraction of localized atomic or pairwise orbitals. Many key properties of biological polypeptides derivefrom the mixing of such localized orbitals that we associate with "resonance" of the amide group. The acidityof carboxylic acids and the aggregation of methyl lithium into solvated tetramers can be understood inanalogous terms. More amazing than the panoply of modern experimental and theoretical tools is that theirresults would not have surprised traditional organic chemists who already had developed an understanding oforganic structure with much cruder tools. The next quarter of the semester is aimed at understanding how ourscientific predecessors developed the structural model and nomenclature of organic chemistry that we stilluse.
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