Open Yale CoursesCHEM 125: Freshman Organic ChemistryLecture 28 - Stereochemical Nomenclature; Racemization andResolution<< previous session| next session >>Overview:Determination of the actual atomic arrangement in tartaric acid in 1949 motivated a change in stereochemicalnomenclature from Fischer's 1891 genealogical convention (D, L) to the CIP scheme (R, S) based onconventional group priorities. Configurational isomers can be interconverted by racemization andepimerization. Pure enantiomers can be separated from racemic mixtures by resolution schemes based onselective crystallization of conglomerates or temporary formation of diastereomers.Problem sets/Reading assignment:Reading assignments, problem sets, PowerPoint presentations, and other resources for this lecture can beaccessed from Professor McBride's on-campus course website, which was developed for his Fall 2008
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