Open Yale CoursesCHEM 125: Freshman Organic ChemistryLecture 31 - Preparing Single Enantiomers and Conformational Energy<< previous session| next session >>Overview:After mentioning some legal implications of chirality, the discussion of configuration concludes usingesomeprazole as an example of three general methods for producing single enantiomers. Conformationalisomerism is more subtle because isomers differ only by rotation about single bonds, which requires carefulphysico-chemical consideration of energies and their relation to equilibrium and rate constants.Conformations have their own notation and nomenclature. Curiously, the barrier to rotation about the C-Cbond of ethane was established by measuring its heat capacity.Problem sets/Reading assignment:Reading assignments, problem sets, PowerPoint presentations, and other resources for this lecture can beaccessed from Professor McBride's on-campus course website, which was developed for his Fall 2008
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