Open Yale CoursesCHEM 125: Freshman Organic ChemistryLecture 32 - Stereotopicity and Baeyer Strain Theory<< previous session| next session >>Overview:Why ethane has a rotational barrier is still debatable. Analyzing conformational and configurationalstereotopicity relationships among constitutionally equivalent groups reveals a subtle discrimination inenzyme reactions. When Baeyer suggested strain-induced reactivity due to distorting bond angles away fromthose in an ideal tetrahedron, he assumed that the cyclohexane ring is flat. He was soon corrected by cleverSachse, but Sachse's weakness in rhetoric led to a quarter-century of confusion.Problem sets/Reading assignment:Reading assignments, problem sets, PowerPoint presentations, and other resources for this lecture can beaccessed from Professor McBride's on-campus course website, which was developed for his Fall 2008
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