7 - Oxidant signals and oxidative stress, Finkel, T.

7 - Oxidant signals and oxidative stress, Finkel, T. - 7....

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7. Summary for oxidant signals and oxidative stress reactive oxygen species (ROS) actively participate in a diverse array of biological processes – normal cell growth, induction and maintenance of the transformed staqte, programmed cell death and cellular senescene different biological outcomes of ROS reflect subtle differences in the level and duration of the oxidant burst or the cellular context that accompanies the oxidative stress Oxidases: New and Old oxidants can be produced by multiple enzymes that use cellular oxygen as a substrate o multisubunit NADPH oxidase– essential role in host defense – protease release from neutrophil and not ROS are required for bacterial destruction – protease release requires NADPH-oxidase-dependent influx of ROS within the phagocytes endocytic vacuoles – oxidant acts as a signaling molecule o myeloperoxidase (MPO) – the ROS generated alters bioactivity of nitric oxide – MPO play a significant role in vascular tone and signalling increased NADPH oxidase increase (ie. Nox1) expression – 10 fold basal hydrogen peroxide level increase – required to maintain transformed states Oxidant Signalling receptor binding of peptide growth factors stimulate ROS production and this oxidant burst is required for downstream signaling
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This note was uploaded on 02/05/2012 for the course BIOLOGY 3u3 taught by Professor Dr.rollo during the Spring '11 term at McMaster University.

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7 - Oxidant signals and oxidative stress, Finkel, T. - 7....

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