8 - redox-dependent transcriptional regulation, Liu, H.

8 - redox-dependent transcriptional regulation, Liu, H. -...

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8. Summary for redox-dependent transcriptional regulation In response to oxidative stress (ROS—reactive oxygen species)—cell induce genes—regulated by some transcription factors—which regulated by level of oxidative stress any enzyme that metabolizes oxygen has capability of producing ROS – can damage membranes, DNA and proteins ROS can serve as signaling molecules o increase in superoxide, or hydrogen peroxide or other ROS involves the activation of intracellular signaling pathways oxidative and nitrosative stress implicated in progression of atherosclerosis and heat failure Response to increase of oxidative stress—active pathways—1. classical cytosolic signaling pathway—signal by low conc. of ROS, 2. Certain transcription factors—directly or indirectly alter their activity—depend on cellular redox conditions. ROS alter vessel wall/myocardium== through a redox dependent change in transcriptional output. Lessons from simple organisms: SoxR, OxyR and Yap1 Bacteria response to either superoxide / hydrogen peroxide== induction of
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8 - redox-dependent transcriptional regulation, Liu, H. -...

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