PS_7_answeers

PS_7_answeers - Bio 115, Winter 2005 Problem set #7, 1....

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Bio 115, Winter 2005 March 4, 2005 Problem set #7, 1. What is a T-loop? What function is it thought to perform? The loop structure formed by telomeres as they fold back on themselves and hide their single stranded G-rich overhang in a heteroduplex structure. T-loops arethough to help stabilize chromosome ends by hiding them from nucleases and theDNA-damage repair machinery. 2. You perform a fluorescence in situ hybridization on human mitotic chromosomes using a probe derived from the centromere of chromosome #3. What do you observe? Every centromere on every chromosome hybridizes to the centromere sequencesfrom chromosome 3. This indicates that the sequences of all centromeres arerelated to each other. 3. How does the position of a centromere along the length of a chromosome (i.e. middle vs near the end) affect its function? It doesn’t. Centromeres can be found at any position on a chromosome (of course, there must still be a telomere). 4. In a diploid organism, how can the homologous recombination machinery be used to repair a double-strand break in a chromosome? Through Gene Conversion.
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PS_7_answeers - Bio 115, Winter 2005 Problem set #7, 1....

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