CHEM 207 - Chapter #12 & #13 - Forensic Serology and DNA

CHEM 207 - Chapter #12 & #13 - Forensic Serology and...

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Forensic Serology and Forensic Serology and DNA DNA
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Background Background Four blood types: A, B, AB,O Unique identification relevant to linking suspect with crime scene Degraded blood samples create a challenge for analysis; DNA typing can help
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Nature of Blood Nature of Blood Blood defined: Complex mixture of cells, enzymes, proteins, inorganic substances Liquid portion of blood is the plasma If blood clots, resulting liquid is serum Antigens reside on surface of cell membranes impart blood-type characteristics to blood
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Antigens Antigens Substances, usually proteins, that stimulate the body to produce antibodies against it Examples include vaccines like polio
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Antibodies Antibodies A protein that destroys or inactivates a specific antigen; found in the blood serum Best examples of antigens and antibodies are the ABO blood system
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Antigen -Antibody Antigen -Antibody Note the different antibody shapes that match different antigens
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Blood types Blood types Blood type A Antigen A Antibodies anti- B B B anti- A AB AB neither O neither anti –A and anti- B
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ABO Distribution, USA ABO Distribution, USA Type O- 43-45% Type A- 40-42% Type B- 10-12% Type AB- 3-5%
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Blood Typing Blood Typing Serology- the study of antigen- antibody reactions Whole blood typing for ABO is the best forensic application, but not performed often due to DNA typing
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Forensic Characterization of Bloodstains Bloodstains Is it blood? What species is it?
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This note was uploaded on 02/03/2012 for the course CHEM 207 taught by Professor Bacon during the Fall '11 term at Ferris State.

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CHEM 207 - Chapter #12 & #13 - Forensic Serology and...

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