32_lecture - Chapter 32 Nonspecific (Innate) Host...

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Unformatted text preview: Chapter 32 Nonspecific (Innate) Host Resistance 1 2 Airway cilia M.pneumoniae Normal bronchiole most pathogens (disease causing microbes) must overcome surface barriers and reach underlying tissue overcome resistance by host nonspecific resistance specific immune response 3 Host Resistance Overview immune system composed of widely distributed cells, tissues, and organs recognizes foreign substances or microbes and acts to neutralize or destroy them immunity ability of host to resist a particular disease or infection immunology science concerned with immune responses 4 Host Resistance Overview nonspecific immune response also called nonspecific resistance , innate immunity , and natural immunity acts as a first line of defense offers resistance to any microbe or foreign material lacks immunological memory 5 Immunity specific immune response also called acquired immunity, adaptive immunity, and specific immunity resistance to a particular foreign agent has memory effectiveness increases on repeated exposure to agent the two types of responses usually work together 6 Immunity 7 Figure 32.1 recognized as foreign invoke immune responses presence of antigen in body ultimately results in B cell activation à à production of antibodies antibodies bind to specific antigens, inactivating or eliminating them other immune cells also become activated name comes from antibody generators 8 Antigens white blood cells (WBCs) play a major role in the innate and specific responses hematopoesis development of white blood cells in bone marrow of mammals WBCs that mature prior to leaving bone marrow, e.g., macrophages and dendritic cells, become part of innate immune system and will respond to all antigens WBCs that are not fully functional after leaving bone marrow become part of the adaptive immune response, e.g., B and T cells and could differentiate in response to specific antigens 9 White Blood Cells of Innate and Adaptive Immunity effectiveness impacted by: direct factors nutrition, physiology, fever, age, and genetics indirect factors personal hygiene, socioeconomic status, and living conditions 10 Physical Barriers in Nonspecific (Innate) Resistance along with hosts secretions (flushing) these barriers are the first line of defense against microbes 11 Physical and Mechanical Barriers strong mechanical barrier to microbial invasion keratin produced by keratinocytes in outer layer inhospitable environment for microbes attached organisms removed by shedding of...
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32_lecture - Chapter 32 Nonspecific (Innate) Host...

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