acetaminophen lab report

acetaminophen lab report - Acetaminophen Acylated aromatic...

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Melting Point Analysis of Crude and Re-crystallized Acetaminophen Synthesized from p-Aminophenol and Acetic Anhydride Corinne Roels and Jacob DeMenna Sudipta Biswas Wed: 12:55-4:45 Lab Experiment 10A & 11
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Abstract: The objective of this lab is to synthesize crude acetaminophen from a given amount of p- aminophenol and acetic anhydride using heat to stimulate the reaction. Crude acetaminophen is then isolated from the excess acetic acid created as a secondary product of the reaction through vacuum filtration. The products are then purified using the standard crystallization procedure. After complete drying and isolation of products, the melting point can be determined in order to identify the accuracy of our purification. Accuracy can also be determined through running our product through a TLC plate against a compound previously identified as pure acetaminophen. With the termination of this experiment, it can be concluded that of our percent yield of the final product is 48%, as 0.0729g of acetaminophen were synthesized from 0.152g p- aminophenol. The experimental compound also can be determined to be acetaminophen through its calculated melting point closely paralleling that of the experimental value 168.2-171.9°C ≈ 169.5-171°C. The results can then be verified further through the analysis of the synthesized acetaminophen against known acetaminophen through thin-layer chromatography. The similarity in Rf values for the spot samples also indicates the identity of the synthesized compound.
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Introduction: The purpose of this experiment was to generate and then isolate pure acetaminophen from a crude sample. The crude sample contained p - aminophenol, which was treated with acetic anhydride to form p -acetamidophenol (acetaminophen). Due to the catalyst of heat, the acetyl group on the acetic anhydride
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acetaminophen lab report - Acetaminophen Acylated aromatic...

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