ExtraCreditHomework1_KEY - Name KEY EID Extra Credit...

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Name: KEY EID: Extra Credit Homework #1 Complete questions below and hand in to a TA by the end of class, Friday, Sept. 2. 1. Draw the structures of the 20 amino acids (in their predominant form at pH 7.0, clearly showing stereochemistry). Indicate the pK a of any side chain that is ionizable. Also provide the three-letter and one-letter codes.
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What is a pirate’s favorite amino acid? Arginine! 2. A 1.0 L solution has a mixture of 0.05 M NaH 2 PO 4 (pK a = 6.86) and 0.10 M Na 2 HPO 4 . How much 1.0 M NaOH should be added to bring the solution to pH 7.4? pH = p K a + log([A - ]/[HA]) 7.4 = 6.86 + log([A - ]/[HA]) [A - ]/[HA] = 10 0.54 = 3.47 3.47 = (A - + x)/(HA – x) = (0.10 + x)/(0.05 – x) 0.174 – 3.47x = 0.10 + x x = 0.017 mol 0.017 mol · 1 L/mol = 0.017 L or 17 mL of 1.0 M NaOH
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3. Taxol exhibits antitumor activity. Label the indicated functional groups. 1. Hydroxyl 2. Ester 3. Amide 4. Ether 5. Keto (carbonyl) 4. Draw out each of these peptides as they exist at the indicated pH (show stereocenters). Indicate the net charge of each peptide at that pH. Also provide the approximate pI for each peptide.
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