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ExtraCreditHomework9KEY - Name KEY EID Extra Credit...

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Name: KEY EID: Extra Credit Homework #9 Complete the questions below and hand in to a TA by the end of class, Monday, Nov 14. 1. Consider glycolysis/gluconeogenesis. a) Which 3 steps of glycolysis are irreversible? List the schemes (not the mechanisms) for these “irreversible” enzymatic transformations, including enzyme names. Step 1, hexokinase: Glucose + ATP glucose 6-phosphate + ADP Step 3, phosphofructokinase: Fructose 6-phosphate + ATP fructose 1,6-bisphosphate + ADP Step 10, pyruvate kinase: Phosphoenolpyruvate + ADP pyruvate + ATP b) What does “irreversible” mean here? Sufficiently large - Δ G that the reaction is unidirectional. c) What gluconeogenic enzymes bypass these reactions? List the schemes (not the mechanisms) for these enzymatic reactions. Referring to the glycolytic steps of part a)… Step 1, glucose 6-phosphatase: Glucose 6-phosphate + H 2 O glucose + P i Step 3, fructose 1,6-bisophosphatase-1: Fructose 1,6-bisphosphate + H 2 O fructose 6-phosphate + P i Step 10a, pyruvate carboxylase: Pyruvate + HCO 3 + ATP oxaloacetate + ADP + P i Step 10b, PEP carboxykinase:
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