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ProteinFoldingb - Protein Folding Energy landscape Protein...

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Protein Structure
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Protein Structure
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Central Dogma of Biology
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Protein Folding in the Cell
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The Hydrophobic Effect
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The Hydrophobic Effect it drives binding
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The Hydrophobic Effect it drives folding
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Protein Structure blue: hydrophobic hydrophobic residues are buried
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Protein Folding Protein unfolding results in loss of function
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Protein Folding Protein unfolding results in loss of function Energy difference ~8-10 kcal mol -1
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Protein Folding Protein unfolding results in loss of function
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Protein Folding Protein (un)folding is highly cooperative
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Protein Folding How does a protein arrive at its native structure? The Levinthal’s paradox: a protein would take ~10 77 years to fold simulated folding pathway Two folding models: the hierarchical and through the “molten globule”
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Unformatted text preview: Protein Folding Energy landscape Protein Folding Energy landscape Protein Folding Death by misfolding: the Prion diseases Protein Folding Chaperones assist newly synthesized proteins to fold Protein Folding Chaperones assist newly synthesized proteins to fold Protein Folding Chaperones assist newly synthesized proteins to fold The GroES-EL chaperonin Protein Folding One sequence, one fold Anfinsen’s hypothesis: Sequence determines structure Protein Folding One sequence, one fold? PNAS, 2008, 105, 5057 Intrinsically Unstructured Proteins Nat. Rev. Mol. Biol., 2005, 6, 199 Intrinsically Unstructured Proteins Nat. Rev. Mol. Biol., 2005, 6, 199 Coupled folding and binding...
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