phosb - Principles of protein phosphorylation Biophysical...

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Principles of protein phosphorylation Biophysical Chemistry 1, Fall 2010 Signalling “cascades” Structural biology of phosphorylation Web assignment: http://pkr.genomics.purdue.edu
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Kinases and phosphatases Kin a ph o se o-
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Signalling overview neral Examples
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Cells are way too complex! MAPK/ERK Signaling Pathway
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Rous sarcoma virus (RSV) Example: Rous sarcoma virus (RSV) ± gag - encodes capsid proteins ± pol - encodes reverse transcriptase ± env - encodes envelope proteins ± src - encodes a tyrosine kinase that attaches phosphate groups to the amino acid tyrosine in host cell proteins
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Mutations, viruses and cancer Example: Rous sarcoma virus (RSV) ± v-src lacks the C-terminal inhibitory phosphorylation site (tyrosine-527), and is therefore constitutively active as opposed to normal src (c-src) ± Continuous cell profileration tumor
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Biophysics of signalling Structural Effect of Phosphorylation Phosphorylation is an important regulatory mechanism Can reversible attach/detach a phosphate and therefore switch
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phosb - Principles of protein phosphorylation Biophysical...

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