BioPhysChem_Fall_2010

BioPhysChem_Fall_2010 - Prerequisites Organic chemistry or...

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16:118:509, 16:160:537 Biophysical Chemistry I 01:160:437 Physical Chemistry of Biological Systems An Introduction to Biomolecular Structure and Interactions Fall Semester, 2010 Instructors Professor David A. Case -- Wright-Rieman Labs, Rm 113; 445-5885; case@biomaps.rutgers.edu Professor Babis Kalodimos -- Biomedical Engineering, Rm 209; 445-4500, x6209; babis@rci.rutgers.edu Time and Place Tuesdays and Thursdays 1:40-3:00 PM Hill Center, Rm 116 Description Three-dimensional structures and interactions of proteins, nucleic acids, carbohydrates, lipids, and their macromolecular assemblies. A primarily descriptive course that emphasizes the connections between molecular structure, interactions, and biological function, and introduces students to the methods used to visualize and analyze macromolecular structures and assemblies. Textbook Liljas et al. Textbook of Structural Biology , World Scientific Publishing Co. (2009); paperback version recommended (ISBN: 978-981-277-208-4)
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Unformatted text preview: Prerequisites Organic chemistry or permission of instructor. One semester of physcial chemistry and one semester of biochemistry recommended. Requirements and Grading Homework (33%), in-class oral presentation (33%), and final written report (34%) Syllabus Week Dates Topics 1 Sept 2 Class introduction 2 Sept 7,9 Representations/visualization of macromolecular structures 3 Sept 14,16 Forces determining macromolecular structure 4 Sept 21, 23 Protein structural principles 5 Sept 28, 30 Protein-protein interactions; phosphorylation and signaling 6 Oct 5, 7 Protein folding and unstructured proteins 7 Oct 12, 14 DNA and RNA 8 Oct 19, 21 Protein/DNA interactions 9 Oct 26, 28 RNA machinery microRNAs to the ribosome 10 Nov 2, 4 Membranes and membrane proteins 11 Nov 9, 11 Enzymes, substrates, and inhibitors 12 Nov 17, 19 Carbohydrates and glycoproteins 13 Nov 23 Viruses 14 Nov 30, Dec 2 Student projects/presentations 15 Dec 7, 9 Student projects/presentations...
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