Phar 303 - Teratogenicity From frogs to human Principles of...

Info iconThis preview shows pages 1–31. Sign up to view the full content.

View Full Document Right Arrow Icon
Géraldine Delbès McGill University [email protected] Teratogenicity: From frogs to human Principles of teratogens action PHAR-303
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Developmental Toxicology: Chapter 10
Background image of page 2
http://www.motherisk.org/women/drugs.jsp http://www.teratology.org/primer.asp http://www.marchofdimes.com/professionals http://otispregnancy.org/otis_fact_sheets.asp A few web sites http://www.healthandenvironment.org/
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
http://awakeupstory.healthychild.org/ http://org2.democracyinaction.org/o/6639/p/dia/action/p ublic/?action_KEY=3503 http://healthandenvironmentonline.com/2010/02/10/10- americans/ A few videos
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
OUTLINE • Teratology- definitions and statistics • Principles of teratology • Examples of teratogens 1. Thalidomide 2. Diethylstibestrol: DES 3. Ethanol 4. Retinoic acid 5. Others 6. Paternal exposure
Background image of page 6
Dicephalic twins Teratology Greek - Teras, Teratos - monster Approx. 4000 years old
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Achondroplasia Gladiator" - Bibliotheque Nationale, Paris - in "Congenital Malformations" by J. Warkany, Year Book Medical Publishers, 1971.
Background image of page 8
Early experimental teratology
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Craniofacial malformations induced by vitamin A Chick embryos
Background image of page 10
Types of body malformations Common Carp larva
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Apparent recent increases in abnormal amphibians. Amphibians
Background image of page 12
This metamorphosing tadpole owes its extra leg to Ribeiroia trematodes (inset) , which are about 500 micrometers long. Amphibians
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Birth defects statistics
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 16
What are the causes of birth defects ?
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Causes of developmental defects in humans
Background image of page 18
OUTLINE • Teratology- definitions and statistics • Principles of teratology • Examples of teratogens 1. Thalidomide 2. Diethylstibestrol: DES 3. Ethanol 4. Retinoic acid 5. Others 6. Paternal exposure
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 20
Timing of exposure is critical
Background image of page 21

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 22
The U.S. EPA’s Strategic Plan for Evaluating the Toxicity of Chemicals, based on the NAS report entitled “Toxicity Testing for the 21 st Century”. Are there shared signaling pathways or targets?
Background image of page 23

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 24
Background image of page 25

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Access to the fetus: not if, when?
Background image of page 26
Background image of page 27

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Manifestations of deviant development
Background image of page 28
Background image of page 29

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
OUTLINE • Teratology- definitions and statistics • Principles of teratology • Examples of teratogens 1. Thalidomide 2. Diethylstibestrol: DES 3. Ethanol 4. Retinoic acid 5. Others 6. Paternal exposure
Background image of page 30
Image of page 31
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/07/2012 for the course PHAR 301 taught by Professor Hales during the Spring '11 term at McGill.

Page1 / 81

Phar 303 - Teratogenicity From frogs to human Principles of...

This preview shows document pages 1 - 31. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online