03LymphosCellInterx

03LymphosCellInterx - Immune Cell Interactions Important...

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Unformatted text preview: Immune Cell Interactions Important Note: Information contained here has been obtained from various sources, and it is to be used exclusively in connection with the course and not for any other purpose. The material is not to be duplicated or distributed in any form. Immune Cell Interactions • Endothelial cells and Neutrophils, Dendritic Cells, T lymphocytes, B lymphocytes • Dendritic Cells and T lymphocytes • Dendritic Cells and B lymphocytes • T lymphocytes and B lymphocytes Interaction between T cells, B cells and a Dendritic Cells T B What happens when a ligand binds to a receptor? • Cells must be able to sense what is happening in their environment (e.g. neutrophils and chemoattractants Lymphocytes and antigen) • Receptor - Ligand interaction Biochemical Rx Signal Transduction Molecular interactions in leukocyte diapedesis Cells and Receptors regulating Innate Immune Responses BLP dsRNA LPS Flagellin CpGDNA TLR ’ s (Toll-Like Receptors) are expressed by cells of the Innate Immune System. These receptors bind different types of microbial molecules and activate the production of in¡ammatory molecules Signal Transduction Signal Transducers Effector Products Pattern Recognition Receptors. Pathogen Associated Molecular Patterns (PAMP ’ s) Crystal structure of TLR ’ s Receptors that bind Antigen Cells that express it Function TLR TCR DC and Mø T cells Binds Antigen...
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03LymphosCellInterx - Immune Cell Interactions Important...

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